2025原著

Zhao Z, Li G, Ohmichi K, Li X, Zhao F, Ishikawa K, Ishikawa R, Nakamura K, Yokota N, Sun Z, Kurahara L-H: Lacticaseibacillus rhamnosus Probio-M9 alters the gut microbiota and mitigates pulmonary hypertension in a rat model. Nutrients 17(18): 2927, 2025

Imakiire S, Kimuro K, Yoshida K, Masaki K, Izumi R, Imabayashi M, Watanabe T, Ishikawa T, Hosokawa K, Matsushima S, Hashimoto T, Shinohara K, Katsuki S, Matoba T, Nakamura K, Hirano K, Tsutsui H, Abe K:
Activated factor X Inhibition ameliorates NF-κB-IL-6-mediated perivascular inflammation and pulmonary hypertension.
Am J Physiol ‒ Lung Cell Mol Physiol 329(1): L183-L196, 2025

2025総説

Kurahara L-H, Li G, Ishikawa R, Ohmichi K, Hirano K: Human breast milk and its impact on inflammatory bowel disease. J Smooth Muscle Res 61: 75-81, 2025

Eto M, Yamazawa T, Kurahara L-H, Yamamura A, Kajiya K, Watanabe M: Expanding diverse horizons in smooth muscle research: a symposium review of “Muscle and Pathology/Health: Frontiers of Translational Research” at the 66th Annual Meeting of Japan Society of Smooth Muscle Research. J Smooth Muscle Res 61: 59-64, 2025.

2024原著

Li X, Kurahara L-H*, Zhao Z, Zhao F, Ishikawa R, Ohmichi K, Li G, Yamashita T, Hashimoto T, Hirano M, Sun Z, Hirano K:
The therapeutic effect of proteinase-activated receptor-1 antagonist on colitis-associated carcinogenesis. Cell Mol Gastroenterol Hepatol 18(1): 105-131, 2024

Hashimoto T*, Hirano K: Effects of mifepristone on adipocyte differentiation in mouse 3T3-L1 cells. Cell Mol Biol Lett 29(1): 45, 2024

Yoshida H, Yamamoto N, Kurahara L-H, Izumori K, Yoshihara A: X-ray structure and characterization of a probiotic Lactobacillus rhamnosus Probio-M9 L-rhamnose isomerase.
Appl Microbiol Biotechnol 108(1): 249, 2024

Zhao F, Hiraishi K, Li X, Hu Y, Kojima D, Sun Z, Zhang H, Kurahara L-H*: Long-term tracking of the effects of colostrum-derived Lacticaseibacillus rhamnosus Probio-M9 on gut microbiota in mice with colitis-associated tumorigenesis.
Biomedicines 12(3): 531, 2024

2024総説

Sykora M, Bacova BS, Andelova K, Benova TE, Martiskova A, Kurahara L-H, Hirano K, Tribulova N: Connexin43, A promising target to reduce cardiac arrhythmia burden in pulmonary arterial hypertension. Int. J. Mol. Sci. 25(6): 3275, 2024

Hirano K: New mechanistic insight into biased signaling of proteinase-activated receptor 1 (Editorial). Arterioscler Thromb Vasc Biol 44: 617‒619, 2024

2022原著

Hiraishi K, Zhao F, Kurahara LH, Li X, Yamashita T, Hashimoto T, Matsuda Y, Sun Z, Zhang H, Hirano K: Lactulose modulates the structure of gut microbiota and alleviates colitis-associated tumorigenesis. Nutrients 14(3): 649, 2022

Hirano M, Hirano K: Critical role of Rho proteins in myosin light chain di-phosphorylation during early phase of endothelial barrier disruption. J Physiol Sci 72: 32, 2022

2022総説

Hiraishi K, Kurahara LH, Ishikawa K, Go T, Yokota N, Hu Y, Fujita T, Inoue R, Hirano K: Potential of TRPM7 channel as a novel therapeutic target for pulmonary arterial hypertension. J Smooth Muscl Res 58: 50-62, 2022

Bacova BS, Andelova K, Sykora M, Egan Benova T, Barancik M, Kurahara LH, Tribulova N: Does Myocardial Atrophy Represent Anti-Arrhythmic Phenotype? Biomedicines 10: 2819, 2022.

2021原著

Watanabe T, Tanaka-Ishikawa M, Abe K, Ishikawa T, Imakiire S, Masaki K, Hosokawa K, Fukuuchi T, Kaneko K, Ohtsubo T, Hirano M, Hirano K, Tsutsui H. Increased lung uric acid deteriorates pulmonary arterial hypertension. J Am Heart Assoc 10: e022712, 2021

Hu Y, Li Q, Kurahara L-H, Shioi N, Hiraishi K, Fujita T, Zhu X, Inoue R: An arrhythmic mutation E7K facilitates TRPM4 channel activation via enhanced PIP2 interaction. Cells 10(5): 983, 2021

Xu H, Hiraishi K, Kurahara L-H, Nakano-Narusawa Y, Li X, Hu Y, Matsuda Y, Zhang H, Hirano K: Inhibitory effects of breast milk-derived Lactobacillus rhamnosus Probio-M9 on colitis-associated carcinogenesis by restoration of the gut microbiota in a mouse model. Nutrients 13: 1143, 2021

Hiraishi K, Kurahara L-H, Feng J, Yamamura A, Cui Y, Yahiro E, Yokomise H, Go T, Ishikawa K, Yokota N, Fujiwara A, Onitsuka M, Abe K, Ohga S, Satoh T, Okada Y, Yue L, Inoue R, Hirano K: Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension. Transl Res 233, 2021, Pages 127-143

Ishikawa T, Abe K, Tanaka-Ishikawa M, Yoshida K, Watanabe T, Imakiire S, Hosokawa K, Hirano M, Hirano K, Tsutsui H: Chronic inhibition of toll-like receptor 9 ameliorates pulmonary hypertension in rats. J Am Heart Assoc 10: e019247, 2021

Sriherfyna FH, Matsutani M, Hirano K, Koike H, Kataoka N, Yamashita T, Nakamaru-Ogiso E, Matsushita K, Yakushia T: The auxiliary NADH dehydrogenase plays a crucial role in redox homeostasis of nicotinamide cofactors in the absence of the periplasmic oxidation system in Gluconobacter oxydans NBRC3293. Appl Environ Microbiol 87(2): e02155-20, 2021

2020原著

Kurahara LH*, Hiraishi K, Yamamura A, Zhang Y, Abe K, Yahiro E, Aoki M, Koga K, Yokomise H, Go T, Ishikawa K, Zhang B, Kishi H, Kobayashi S, Aoki-Shoi N, Satoh T, Inoue R, Hirano K: Eicosapentaenoic acid ameliorates pulmonary hypertension via inhibition of tyrosine kinase Fyn. J Mol Cell Cardiol 148: 50-62, 2020

2020総説

Tribulova N, Kurahara LH, Hlivak P, Hirano K, Bacova BS: Pro-arrhythmic signaling of thyroid hormones and its relevance in subclinical hyperthyroidism. Int J Mol Sci 21(8): 2844, 2020

2019原著

Liu W, Hashimoto T, Yamashita T, Hirano K*: Coagulation factor XI induces Ca2+ response and accelerates cell migration in vascular smooth muscle cells via proteinaseactivated receptor 1. Am J Physiol – Cell Physiol 316: C377-C392, 2019 (PMID: 30566391)

Kuwabara Y, Tanaka M, Abe K, Hirano M, Hirooka Y, Tsutsui H, Sunagawa K, Hirano K*: Proteinase-activated receptor 1 antagonism ameliorates experimental pulmonary hypertension. Cadiovasc Res 115: 1357-1368, 2019 (PMID: 30423156)

　<Editorial comment for Kuwabara et al.>

Merkus D, van Beusekom HMM, Boomars KA. Protease-activated receptor 1 as potential therapeutic target in pulmonary arterial hypertension. Cardiovasc Res 115: 1260-1261, 2019

Nakai K, Karita S, Igarashi J, Tsukamoto I, Hirano K, Kubota Y: COA-Cl prevented TGF-β1-induced CTGF expression by Akt dephosphorylation in normal human dermal fibroblasts, and it attenuated skin fibrosis in mice models of systemic sclerosis. J Dermatol Sci 94(1): 205-212, 2019 (PMID: 30954335)

Bai X, Ihara E, Otsuka Y, Tsuruta S, Hirano K, Tanaka Y, Ogino H, Hirano M, Chinen T, Akiho H, Nakamura K, Oda Y, Ogawa Y: Involvement of different receptor subtypes in prostaglandin E2-induced contractionand relaxation in the lower esophageal sphincter and esophageal body. Eur J Pharmacol 857: 172405, 2019 (PMID: 31128092)

Sykora M, Bacova BS, Benova TE, Barancik M, Zurmanova J, Rauchova H, Weismann P, Pavelka S, Kurahara HL, Slezak J, Soukup T, Tribulova N: Cardiac Cx43 and ECM Responses to Altered Thyroid Status Are Blunted in Spontaneously Hypertensive versus Normotensive Rats Int. J. Mol. Sci. 2019, 20(15), 3758

2019総説

Usui-Kawanishi F, Takahashi M, Sakai Hm Suto W, Kai Y, Chiba Y, Hiraishi K, Kurahara LH, Hori M, Inoue R: Implications of immune-inflammatory responses in smooth muscle dysfunction and disease. J Smooth Muscl Res 55(0): 81-107, 2019