原著

Li G., Zhao Z., Zhao F., Ishikawa M., Kumamoto K., Ohmichi K., Ishikawa R., Yamazaki S., Sun Z., Kurahara LH*
Probio-M9 and Genetic Senolysis Attenuate Experimental Colitis by Targeting Inflammation-Associated Cellular Senescence
Engineering 2026 in press

Tetsuo Yamashita*, Noriyuki Kodera, Masumi Eto, Risa Omura, Mayumi Hirano, Takeshi Hashimoto, and Katsuya Hirano*: 
Small subunit M20 augments inhibitory phosphorylation of MYPT1 in myosin light chain phosphatase by inhibiting autodephosphorylation
PNAS. 123: 30, 2026

Tsurudome N, Yamashita T, Mochioka R, Morokuma M, Hirano K*:
Contribution of polyphenols in wine grape extract to the inhibition of serine protease activity and proteinase-activated receptor 1-mediated Ca2+ signaling in vascular endothelial cells　
Fitoterapia 193: 107367, 2026

Li X, Hiraishi K, Kumamoto K, Nakakita S, Yamashita T, Kamitori K, Ohmichi K, Ishikawa R, Kurahara L-H*:
D-Allose suppresses colitis associated carcinogenesis by reversing ER stress in macrophages and inhibiting cancer cell proliferation
Front. Immunol. 17: 1737504, 2026

Li G, Zhao Z, Machitani M, Ishikawa R, Ishikawa K, Yokota N, Haba R, Nakamura K, Sun Z, Kurahara L-H*, Hirano K:
Elucidation of mechanisms underlying the therapeutic effects of cordycepin on pulmonary hypertension, with a focus on cell senescence and gut microbiota
Biomed Pharmacother 194: 118923, 2026

総説

倉原琳：肺高血圧症と細胞老化 （キーワード解説）日本薬理学雑誌, 161 (1): 55-56, 2026

プレスリリース

2026年7月24日、PNAS論文に関するプレスリリース「血圧や細胞運動を制御する酵素の新たな制御機構を解明」が香川大学より発表され、記者クラブへの送付および大学ホームページへの掲載が行われました。

学会発表：招待講演，シンポジウムなど

平野勝也：
進歩　～過去・現在・未来～
令和７年度香川大学退職教員の最終講義
March 19, 2026, Miki-cho, Kagawa, Japan

平野勝也：
平滑筋ミオシン軽鎖脱リン酸化酵素調節におけるM20サブユニットの新たな機能. 第103回日本生理学会シンポジウム「心血管システムの階層的制御機構：分子・細胞・臓器連関から探る新たな生理学的パラダイム」
March 12 (11-12), 2026, Tokyo, Japan 
J Physiol 76 (1) Supplement: 90, 2026

学会発表：国内学会一般演題

第67回日本生化学会中国四国支部例会（香川県木田郡三木町、2026年5月30日-31日）
山下哲生、古寺哲幸、江藤真澄、太村理沙、平野真弓、橋本剛、平野勝也：
ミオシン軽鎖脱リン酸化酵素サブユニットM20はMYPT1の二量体形成を抑制し自己脱リン酸化を阻害する

第103回日本生理学会大会（東京、2026年3月10日-12日）
Tsurudome N, Hirano K:
Factor Xa inhibition promotes metabolic aging in a sexdependent manner in mice
J Physiol Sci 76 (1) Supplement: 195, 2026

Miyagawa Y, Kurahara L, Takeya K, Matsui T, Hirano K, Eto M: 
A novel type 1 Ser/Thr Pphosphatase regulatory protein GBPI expressed in gastrointestinal mucosal epithelial cells: Change in cellular localization dependent on epithelial differentiation
J Physiol Sci 76 (1) Supplement: 237, 2026

Li G, Zhao Z, Machitani M, Ishikawa R, Ishikawa K, Nakamura K, Kurahara L-H, Hirano K:
Therapeutic effect of Cordycepin on pulmonary hypertension: Focusing on the p53/CDK1/TERT axis and gut microbiota
J Physiol Sci 76 (1) Supplement: 285, 2026

Yamashita T, Kodera N, Eto M, Omura R, Hirano K:
The small subunit M20 suppresses auto-dephosphorylation of MYPT1 inhibitory phosphorylation in myosin light chain phosphatase
J Physiol Sci 76 (1) Supplement: 305, 2026

Hashimoto T, Ishikawa R, Omichi K, Hirano K:
Potential contribution of increased small adipocyte population and suppression of TNFα expression in adipose tissues to suppression of age-associated insulin resistance in PAR1 knockout mice
J Physiol Sci 76 (1) Supplement: 306, 2026

Sunaga D, Hirano M, Hirano K:
Lipid deposition induces endothelial-to-mesenchymal transition in senescent endothelial cells
J Physiol Sci 76 (1) Supplement: 329, 2026